Mahdiyehsadat Eftekharafzali; Mitra Mehrabani; Haleh Tajadini; Bijan Ahmadi; Mohammad Javad Zahedi
Volume 20, Issue 7 , July 2018, , Pages 1-7
Abstract
Background: Functional dyspepsia (FD) is one of the most common problems around the world. Pistacia atlantica has beneficial effects in gastrointestinal disorders and is used for treating functional dyspepsia in Persian Medicine.Objectives: The aim of this study was to assess the effect of “Pistacia ...
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Background: Functional dyspepsia (FD) is one of the most common problems around the world. Pistacia atlantica has beneficial effects in gastrointestinal disorders and is used for treating functional dyspepsia in Persian Medicine.Objectives: The aim of this study was to assess the effect of “Pistacia atlantica” (Baneh) on functional dyspepsia.Methods: This randomized, double-blind, placebo-controlled trial was carried out on 119 patients (18 to 60 years old) with func- tional dyspepsia based on Rome III criteria. Subjects were randomly divided to intervention (n = 61) and placebo (n = 58) groups. Participants received capsules twice daily (500 mg capsules containing 350 mg Pistacia atlantica resin plus 150 mg sugar in the inter- vention group, and 500 mg capsules containing 350 mg starch powder plus 150 mg sugar in the placebo group) for four weeks and they were followed up for one month. The intensity and frequency of gastrointestinal symptoms, such as fullness, bloating, nausea, pain, and burning were assessed using the questionnaire on arrival, two and four weeks, and one month after the intervention. Results: Fifty-three patients in the Pistacia atlantica group and 48 patients in the placebo group completed the study. The severityand frequency of gastrointestinal symptoms, such as early satiation nausea, pain, and burning were significantly decreased in the Pistacia atlantica group. For example, severity of early satiation was 1.67 ± 0.13 in pistacia and 2.54 ± 0.17 in placebo groups in eight weeks (P > 0.001) and frequency of this symptom was 2.39 ± 0.27 and 4.41 ± 0.34 in Pistacia and placebo groups, respectively, in eight weeks (P > 0.001), which was significantly decreased in the Pistacia group. No serious adverse effects were reported. Conclusions: This study revealed that Pistacia atlantica is significantly effective in functional dyspepsia symptoms.
Shahrbanoo Abdolhosseini; Fataneh Hashem-Dabaghian; Roshanak Mokaberinejad; Omid Sadeghpour; Mitra Mehrabani
Volume 19, Issue 10 , October 2017, , Pages 1-10
Abstract
Background: Nausea and vomiting during pregnancy (NVP) affects approximately 50% - 80% of expecting mothers. NVP can impose negative effects on the quality of life; therefore, more attention should be paid to improve patients’ health outcomes.Objectives: The purpose of this trial was to evaluate ...
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Background: Nausea and vomiting during pregnancy (NVP) affects approximately 50% - 80% of expecting mothers. NVP can impose negative effects on the quality of life; therefore, more attention should be paid to improve patients’ health outcomes.Objectives: The purpose of this trial was to evaluate the efficacy of pomegranate and spearmint syrup on NVP.Methods: In this randomized clinical trial, 74 pregnant women with moderate NVP were divided into 2 groups via block randomization method. A total of 24 and 31 patients were analyzed in the syrup and vitamin B6 groups, respectively. The 24-hour pregnancyunique quantification of emesis (PUQE-24) scale was used to examine the severity of NVP. The intervention included the use of pomegranate syrup (5 cc/TDS) plus vitamin B6 in the syrup group; on the other hand, the control group only received B6 tablets (20 mg/TDS) for 1 week. The subjects were followed-up for 1 week without any interventions. Data were analyzed, using Chi square test for qualitative variables, t test and Mann-Whitney U test for quantitative variables, and Friedman test for repeated measures.Results: There was no significant difference between the groups in terms of demographic and pregnancy characteristics. The mean PUQE-24 score in the syrup group was 9.4 ± 1.8 at baseline, 4.6 ± 1.5 on day 7, and 4.8 ± 2.6 on day 14 (P < 0.001). The mean PUQE-24 score in the control group was 8.5 ± 1.5 at baseline, 6 ± 2.3 on day 7, and 6.2 ± 2.6 on day 14 (P < 0.001). Although a major decline in PUQE-24 scores was observed in both groups, it was more significant in the syrup group (P = 0.001). Also, the PUQE-24 score was significantly lower in the syrup group, compared to the control group on days 7 and 14 (P = 0.02). The visual analog scale scores also showed a greater reduction in the syrup group, compared to the control group (4.7 ± 2.8 vs. 1.6 ± 3; P = 0.001). No significant difference was observed between the groups regarding the duration of nausea, frequency of vomiting, and frequency of retching; also, no complications were reported.Conclusions: The effectiveness of pomegranate and spearmint syrup in reducing NVP was confirmed in the syrup group versus the control group with significant differences.
